An exploratory assessment of the risk of lung cancer associated with exposure to diesel exhaust based on a study in rats.
Authors
Smith R; Stayner L
Source
Respirable dust in the mineral industries, proceedings of the 3rd symposium on respirable dust in the mineral industries, October 17-19, 1990, Pittsburgh, Pennsylvania. Frantz RL, Ramani RV, eds. Littleton, CO: Society for Mining, Metallurgy, and Exploration, Inc., 1991 Jan; :29-49
Link
NIOSHTIC No.
00209234
Abstract
The risk of lung cancer among miners with occupational exposure to diesel exhaust was quantitatively assessed. The effects of chronic exposure to diesel fumes on Fischer-344-rats formed a large part of the basis for this report. The tumor response data was modeled using an adaptation of the Armitage-Doll multistage model. This model includes an age/dependent effect of exposure analysis. All tumors, benign and malignant, were fitted to this model. The model was also fitted to the malignant tumors only. Based on a linear approximation the results from the multistage model were used to estimate unit risk or potency. To scale the results from airborne exposure in rats to humans, a biologically equivalent dose was developed. This dose was adjusted for differences in weight, ventilation rate, deposition fraction, and the percentage of time actually exposed. Comparisons were made with the risk estimates derived from modeling other rat inhalation bioassays and from the use of different models. Based on these findings, the excess risk to miners of lung cancer at the upper range of the diesel particulate exposure was approximately 1.5 to 3 in 100.
Respirable dust in the mineral industries, proceedings of the 3rd symposium on respirable dust in the mineral industries, October 17-19, 1990, Pittsburgh, Pennsylvania
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.