Oncogenes and oncoproteins in occupational carcinogenesis.
Scand J Work Environ Health 1992 Feb; 18(Suppl 1):27-30
The oncogene theory of carcinogenesis was reviewed and discussed in relation to occupational carcinogenesis. The theory was based on the premise that there are preexisting, normally innocuous genes in the human genome which become inappropriately activated during the process of carcinogenesis, changing them into genes capable of causing the active transformation of cells. Oncogenes may produce their effects through the action of their protein products, called oncoproteins. Oncoproteins include growth factors, membrane receptors, signal transducing G-proteins, protein kinases, and nuclear proteins. The ras oncogene was first identified in acute transforming retroviruses which induced rat sarcomas. Cell culture experimentation resulted in the identification of the p21 protein product which is responsible for the transforming activity of activated ras genes in cells. The neu oncogene was first identified in a model animal system dependent on chemical induction of tumors by alkylating agents such as N-nitroso compounds. It was expected that certain oncogenes will be found to play critical roles in some cases of occupational carcinogenesis as studies in this area continue.
NIOSH-Publication; NIOSH-Grant; Oncogenesis; Genotoxic-effects; Oncogenic-agents; Cell-transformation; Gene-mutation; DNA-damage; Protein-chemistry; Protein-synthesis; Cytotoxic-effects;
Author Keywords: ras; p21; neu/c-erbB-2/HER-2; p18S
Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
Scandinavian Journal of Work, Environment & Health
Columbia University New York, New York, New York