The effects of evaporation and condensation on aerosols in inhalation exposure systems were studied. A mathematical model designed to predict and evaluate changes in the particle size and composition of monodisperse aerosols in the absence of chemical reactions was presented. Equations governing the evaporation and condensation of up to two volatile components were presented, and a set of simplified equations was derived to facilitate the prediction of the effects of evaporation and condensation in inhalation exposure systems. Predictions obtained using the simplified equations were compared to results obtained using the original model for systems containing one volatile component, with and without salt. For cases with two volatile components, the simplified equations were not applicable. Examples of calculations with two volatile components were presented. The model was used to simulate the passage of a volatile aerosol through an inhalation exposure system. The authors conclude that the model presented can predict evaporation and condensation of aerosols by simulating passage through an inhalation exposure system and into the respiratory tract.
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