Occupational Medicine: Principles and Practical Applications, Second Edition. Zenz C, ed., Chicago: Year Book Medical Publishers, Inc., 1988 Jan; :1013-1015
The occupational health hazards and toxicity of carbon-disulfide (75150) were reviewed. Carbon-disulfide was noted to be primarily absorbed through the lungs, and also through the skin and the gastrointestinal tract if swallowed. Workers exposed to high concentrations of carbon-disulfide have been observed to experience narcosis and respiratory failure. Exposure to lower concentrations resulted in headache, dizziness, respiratory irritation, and gastrointestinal disturbances. Chronic carbon-disulfide exposure resulted in central and peripheral nervous system dysfunction, gastrointestinal changes, cardiovascular disease, and mental illness. Studies have shown that workers exposed to carbon- disulfide show frequent occurrence of microscopic aneurysms in the retina and retinopathy. The United States permissible exposure limit to carbon-disulfide was 20 parts per million time weighted average in an 8 hour day. Regular hygienic surveys were recommended to ascertain concentrations of carbon-disulfide in the workplace. The author concludes that workers should be periodically examined by a doctor. Proper engineering controls such as air supplied respirators and suitable protective equipment for the eyes and skin should also be available.
Acute-toxicity; Biological-monitoring; Chronic-toxicity; Humans; Neurotoxicity; Occupational-exposure; Organic-sulfides; Toxic-effects; Exposure-levels
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Occupational Medicine: Principles and Practical Applications, Second Edition