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Health hazard evaluation report: HETA-91-178-2220, Geisinger Wyoming Valley Medical Center, Wilkes Barre, Pennsylvania.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 91-178-2220, 1992 May; :1-28
In response to a request from the Director of Diagnostic Services of Geisinger Wyoming Valley Medical Center (SIC-8062), Wilkes Barre, Pennsylvania, an evaluation was undertaken of new control methods for ribavirin (36791045) administration which had been implemented in 1991. A plastic enclosure was installed which was designed to contain the aerosol in the administration area. Supplied air hood respirators were required for health care workers and visitors when entering the plastic enclosed administration area. Air sampling was conducted, room ventilation rates were measured, engineering controls were evaluated, and the respiratory protection policy and equipment were reviewed. The administration monitored was over a 16 hour period for a 5 month old infant. Twelve inch cubical delivery hoods and small particle aerosol generators were used for administering the drug. A range of 125 to 670 micrograms per cubic meter for ribavirin concentrations was determined in the short term breathing zone samples. Samples taken from inside the supplied air respirator had no detectable ribavirin. Nurses and respiratory therapists were able to put on the hoods with no trouble and they did not interfere with their tasks. The author concludes that exhausted plastic enclosures maintained under negative pressure may be able to control the spread of ribavirin aerosol to adjacent areas. The use of supplied air respirators was feasible as a control method. The author recommends that training and improvements in the respirator program be instituted.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; HETA-91-178-2220; Region-3; Hazard-Unconfirmed; Health-care-personnel; Nursing; Drugs; Respiratory-protective-equipment; Occupational-exposure; Control-technology; Author Keywords: General Medical and Surgical Hospitals; ribavirin; Virazole(R); 1-beta-D-ribofuranosyl-1,2,4-triazole3-carboximide; aerosolized drugs; aerosolized pharmaceuticals; health care workers; teratogen; respirators; aerosol containment system
Field Studies; Hazard Evaluation and Technical Assistance
NTIS Accession No.
National Institute for Occupational Safety and Health
PA; WY; OH
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division