Rank Analysis of Urine Data to Identify Differentially Exposed Subcohorts for a Uranium Enrichment Mortality Study.
NIOSH 1988 May:27 pages
As part of a cohort mortality study at a uranium enrichment facility, investigators used urinalysis data collected by the facility to identify three department based subcohorts exposed to uranyl-fluoride (7783815). Each subcohort was considered to represent employees at greater exposure risk. Details are presented concerning the development and application of the methods of subcohort identification. Inhalation of uranyl-fluoride was the primary exposure of concern at this facility. For the first subcohort selection method all workers who were ever employed in departments in which at least 100 urine uranium (7440611) analyses had been reported over the 28 year span of the data base were included. An additional method was used which allowed two additional subcohorts to be taken from the first cohort. The method was based on the assumption that a department having a greater percentage of measurements exceeding action level criteria had a greater exposure potential. The usefulness of these methods for identifying differentially expose subcohorts using urinalysis data was explored. These methods of subcohort identification were intended to supplement exposure characterization methods employed in epidemiologic studies based on duration of employment and job description. Advantages and disadvantages of the methods were discussed.
NIOSH-Author; Field-Study; IWS-121-10B; Mortality-surveys; Epidemiology; Urinalysis; Biological-monitoring; Radiation-exposure; Occupational-exposure; Uranium-compounds;
NTIS Accession No.
NIOSH, Cincinnati, Ohio, Report No. IWS-121-10B, 27 pages, 8 references