The clinical relevance of asbestos-induced pleural fibrosis.
Ann NY Acad Sci 1991 Dec; 643:169-177
The association between asbestos (1332214) induced pleural fibrosis and parenchymal changes was investigated in 1211 asbestos exposed sheet metal workers. Of those having pleural fibrosis, circumscribed plaques were seen in 260 and diffuse pleural thickening was seen in 74. Pulmonary function testing, high resolution computed tomographic (HRCT) scans of the lung parenchyma, and bronchoalveolar lavage were performed. The presence of circumscribed plaques was related to significant decrements in forced vital capacity (FVC) and one second forced expiratory volume. Workers with diffuse pleural thickening had significant decrements in FVC, total lung capacity (TLC), and carbon-monoxide diffusion capacity (DLco) after controlling for age, years in the trade, and pack years of smoking. This group also exhibited an increased percentage of lymphocytes in their lavage fluid and parenchymal abnormalities on their HRCT scans. Workers with circumscribed plaques also had elevated lavage fluid lymphocyte populations and HRCT parenchymal abnormalities. Circumscribed plaques and diffuse pleural thickening were responsible for a 14% decrease in FVC, a 13% decrease in TLC, and an 11% decrease in DLco.
NIOSH-Grant; Pulmonary-system-disorders; Asbestos-dust; Occupational-exposure; Metal-workers; Chest-X-rays; X-ray-analysis; Lung-fibrosis; Pulmonary-function-tests
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
Pulmonary System Disorders
Annals of the New York Academy of Sciences
University of Iowa, Iowa City, Iowa