Airway injury in swine confinement workers.
Schwartz-DA; Landas-SK; Lassise-DL; Burmeister-LF; Hunninghake-GW; Merchant-JA
Ann Intern Med 1992 Apr; 116(8):630-635
Lung disease among workers in swine confinement buildings was studied to determine if respiratory alterations are attributable to airway or interstitial injury. Participants were selected from a cohort of 207 swine confinement workers (SCWs); referents were blue collar workers whose farming work ended 5 years before the study. Testing included chest radiographs, spirometric evaluation, and assessment of lung volumes and diffusing capacities. A methacholine challenge was performed and a 10% decrease in forced expiratory volume was calculated. Endobronchial (EB) biopsy and bronchoalveolar lavage (BAL) were performed on all study subjects and inflammatory cells were counted. With respect to the referents, SCWs exhibited more work related symptoms and chronic respiratory complaints and also exhibited enhanced airway response to methacholine. BAL cellularity was similar in all groups and there was no evidence of alveolitis among SCWs. EB differences were restricted to thickening of the bronchial basement membranes in the SCW. The authors conclude that symptomatic SCWs are at risk for airway but not parenchymal lung injury.
NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system-disorders; Animal-husbandry-workers; Epidemiology; Lung-disorders; Occupational-exposure; Occupational-respiratory-disease
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
Annals of Internal Medicine
University of Iowa, Iowa City, Iowa