Macromolecular adducts and related biomarkers in biomonitoring and epidemiology of complex exposures.
Perera F; Jeffrey A; Santella RM; Brenner D; Mayer J; Latriano L; Smith S; Young TL; Tsai WY; Hemminki K; Brandt-Rauf P
Complex mixtures and cancer risk. Vainio H, Sorsa M, McMichael AJ, eds. Lyon: International Agency for Research on Cancer, IARC Scientific Publications No. 104, 1990 Jan; :164-180
Recent developments in the use of macromolecular adducts and complementary markers in biomonitoring and molecular epidemiology were reviewed, with emphasis on those which are most pertinent to the evaluation of carcinogenic risks of complex mixtures. Three types of exposures were evaluated: lifestyle related (cigarette smoking); occupational; and clinical. In the first two types of exposure, the common denominator was exposure to multiple polycyclic aromatic hydrocarbons and aromatic amines. Examples of cross sectional, longitudinal serial sampling, retrospective and nested case control studies are described. The advantages and disadvantages of each approach were considered. Chemical specific dosimeters, such as DNA and protein adducts, should be used in conjunction with nonspecific markers such as sister chromatid exchange, micronuclei, gene mutation and oncogene activation which give an integrated estimate of the genotoxic/procarcinogenic effect of exposure. A step wise evaluation can be carried out to separate the effect of specific constituents of the mixture. The most informative designs for identifying the relationship between exposure to complex mixtures and markers of biological dose and effect were serial sampling studies. The nested case/control study was the optimal design to evaluate the role of complex mixtures in cancer risk. The authors suggest that suitable exposures for such study include cigarette smoking, occupational exposures to fossil fuel combustion products and combination chemotherapy.
NIOSH-Publication; NIOSH-Grant; Cancer-rates; Risk-factors; Carcinogenesis; DNA-damage; Protein-chemistry; Genotoxic-effects; Chromosome-damage; Dosimetry; Cigarette-smoking; Occupational-exposure; Polycyclic-aromatic-hydrocarbons
Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
Vainio H; Sorsa M; McMichael AJ
Complex mixtures and cancer risk
Columbia University New York, New York, New York