The health hazards involved in making handmade quilts involving a cyanotype printing process were evaluated. An artist engaged in creation of handmade quilts in her residence had experienced facial and finger edema, mucous membrane irritation, headaches, and nausea, was investigated. The cyanotype process was used to transfer photographic prints to fabric, which was later incorporated in quilts. Chemicals used in the cyanotype process included potassium- dichromate (7778509), which is known to be highly toxic and a skin sensitizer. Even though the artist had discontinued use of the process, symptoms recurred when she handled or sewed cloth treated with the cyanotype process. Work surfaces tested positive for contamination with hexavalent chromium (CrVI). Air and vacuum sampling indicated that CrVI was not present at detectable levels. The author recommended discontinuing the use of the cyanotype process, or discontinue use of potassium-dichromate as fixative, decontaminating the basement with soap and water, washing fabrics thoroughly in hot water, and avoiding contact with other sources of chromates.