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Potential role of platelet-activating factor in development of occupational lung disease: action as an activator or potentiator of pulmonary phagocytes.

Kang JH; Dyke K; Pailes WH; Castranova V

Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, 1992 Jan; :1-30

00205496

This study was designed to investigate whether platelet activating factor may be important in the inflammatory response of the lung to occupational dusts. The in-vitro exposure of alveolar macrophages to cotton dust at 4mg/kg, silica (14808607) at 10mg/ml, or coal dust at 10mg/kg caused a release of picomole levels of platelet activating factor with cotton dust being the most potent and coal dust the least. The platelet activating factor was released from alveolar macrophage about 10 minutes after in-vitro silica exposure. Platelet activating factor is a direct stimulant of polymorphonuclear leukocytes increasing chemiluminescence 2.3 times above control. The response of polymorphonuclear leukocytes to a second stimulant was also potentiated by platelet activating factor. Platelet activating factor was not a direct stimulant of alveolar macrophages in-vitro, having no stimulatory effect on chemiluminescence or superoxide anion release. Platelet activating factor did potentiate zymosan stimulated activation of chemiluminescence and superoxide release from alveolar macrophages by 117 and 30, respectively. The authors conclude that exposure of lung tissue to occupational dusts results in the release of platelet activating factor which may activate polymorphonuclear leukocytes and potentiate the responsiveness of alveolar macrophages to dust.

NIOSH-Author; Respiratory-system-disorders; Lung-cells; Alveolar-cells; Immunology; Blood-analysis; Blood-cells; Dust-exposure; Dust-inhalation; Silica-dusts; Plant-dusts

14808-60-7

19920101

Other

1992

PB92-176775

A03

DRDS

Potential role of platelet-activating factor in development of occupational lung disease: action as an activator or potentiator of pulmonary phagocytes.

WV