School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 1991 Jul; :1-32
The relationship between liver disease and prior exposure to hepatotoxic agents was investigated in four separate studies. The first was a cross sectional study of hazardous waste workers who were well protected. This study examined the relationship between abnormal liver injury tests and obesity. The second study was a case/control study of fatty liver disease. Third was a reanalysis of the data collected by the National Health and Nutrition Examination Survey-II which examined the effect of diabetes, alcohol, obesity and job categories on liver function tests. The fourth was a case/control study of end stage liver disease. The conclusions drawn from these studies were that obesity and occupational exposure to hepatotoxicants were both risk factors, but were independent of one another, for fatty liver disease; that exposure to hepatotoxicants for less than 1 week was not associated with the incidence of fatty liver disease; that there was no consistent risk factor for end stage liver disease in general; that a strong relation was noted for alcohol with end stage liver disease that was attributed to alcohol; that no contribution was found of obesity to the development of end stage liver disease; and that prior hepatotoxicant exposure may be a risk factor for liver disease which is related to autoimmune phenomena and cryptogenic cirrhosis.
NIOSH-Grant; Grants-other; Liver-damage; Risk-analysis; Risk-factors; Alcoholism; Occupational-exposure; Body-weight; Hazardous-materials
Medicine University of Pittsburgh 149 Lothrop Hall Pittsburgh, PA 15261
Final Grant Report
NTIS Accession No.
Other Occupational Concerns; Grants-other
School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
University of Pittsburgh at Pittsburgh, Pittsburgh, Pennsylvania