A study of job activities (dimensions) associated with severe disability due to cardiovascular disease was conducted. The study material consisted of disability data obtained in a 1978 national survey of 5648 nonhospitalized persons in the general population and 4207 severely disabled persons who had applied for benefits from the Social Security Administration (SSA), and the Position Analysis Questionnaire (PAQ) data set. The PAQ was a data base that contained excerpt ratings (scores) of job dimensions for 2485 occupations. The two data sets were combined such that job dimension data were imputed for each occupation contained in the SSA disability data. A factor analysis was performed to determine which job dimensions could be associated with severe cardiovascular disease disability. Thirty two general job dimensions were identified. Odds ratios (ORs) for severe cardiovascular disease disability were calculated for the 32 PAQ job dimension scores after partitioning the scores into quartiles. The first quartile was used as the standard. Seventeen job dimensions associated with severe cardiovascular disease disability were identified. Thirteen of these were also associated with noncardiovascular disease related illnesses. Job dimensions that were specifically associated with an elevated risk of severe cardiovascular disease disability were hazardous work, vigilance plus responsibility, exchanging job information, and watching devices. These had ORs of 4.09, 2.80, 2.09, and 1.09, respectively. Transportation jobs, teachers, and craftsmen/foremen were associated with high scores on these job dimensions.