Visible-light system for detecting doxorubicin contamination on skin and surfaces.
Van Raalte-J; Rice-C; Moss-CE
Am J Hosp Pharm 1990 May; 47(5):1067-1074
An investigation was conducted to develop a safe, portable method for identifying worker exposure to doxorubicin-hydrochloride (25316409). Doxorubicin fluoresces, emitting orange red light in the 580 nanometer range, when activated by violet blue light in the 465 nanometer range. The light system consisted of a Kodak Model AF-1 Ektagraphic slide projector fitted with a new General Electric ELH multi-morrow 300 watt, 120 volt tungsten halogen projection lamp of 3350 kelvin color temperature. The optical system of the projector was equipped with a condensing lens and an infrared filter. The slide compartment of the projector held a Melles-Groit, Model BG-12 glass filter that selectively passed short wave blue visible light. Doxorubicin fluorescence was both observed visually with viewing spectacles and photographed. Doxorubicin was visualized at concentrations as low as 0.002mg/ml or 1/2000 of the clinically administered concentration with this system. Since only visible light was used, concern about exposure to ultraviolet radiation was eliminated. The authors conclude that the system can be used to evaluate dermal or surface contamination by doxorubicin and to evaluate the effectiveness of methods used to remove the drug once spilled.
NIOSH-Author; Health-care-personnel; Laboratory-workers; Chlorides; Occupational-exposure; Nurses; Skin-exposure; Antineoplastic-agents; Pharmaceuticals; Analytical-processes
American Journal of Hospital Pharmacy