Effect of smoke inhalation on immediate changes in lung chemical mediators.
Witten ML; Lantz RC; Grad R; Seidner S; Hubbard AK; Quan SF; Lemen RJ
Res Commun Chem Pathol Pharmacol 1991 Dec; 74(3):259-271
The immediate effects of smoke on alveolar function were assessed in rabbits. Anesthetized and ventilated New-Zealand-white-rabbits received 60 tidal volume breaths of diesel fuel/polycarbonate plastic smoke or sham smoke by injection into the endotracheal tube. After each breath of smoke, four to six ventilated breaths of air were given to each rabbit. The smoke was administered over a period of 8 to 9 minutes. Following exposure, the rabbits were killed and their lungs removed for lavage. Compared to the sham exposure group, the smoke exposure group exhibited a significant increase in leukotriene-B4 levels in lavage fluid with acute exposure. This group also exhibited decreased lung surfactant levels and decreased alveolar macrophage superoxide secretion after phorbol-myristate- acetate stimulation. The authors conclude that these alterations in chemical mediators may play a role in the lung injury caused by smoke inhalation.
NIOSH-Author; Laboratory-animals; Smoke-inhalation; Respiratory-irritants; Lung-cells; Cell-function; Acute-exposure; Combustion-products; Inhalation-studies
Research Communications in Chemical Pathology and Pharmacology