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Criteria for a recommended standard... occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 91-119, 1991 Sep; :1-296
Occupational health risks associated with exposure to ethylene- glycol-monomethyl-ether (109864) (EGME), ethylene-glycol-monoethyl- ether (110805) (EGEE), ethylene-glycol-monomethyl-ether-acetate (110496) (EGMEA) and ethylene-glycol-monoethyl-ether-acetate (110496) (EGEEA) were examined. The glycol ethers were shown to adversely affect the blood, central nervous and hematopoietic systems, liver and kidneys. Dose related malformations, growth retardation and embryonic death have been demonstrated in the offspring of pregnant animals exposed to airborne concentrations of these chemicals. Testicular atrophy and infertility occurred in male animals exposed to airborne EGME or EGEE at or below their current PELs. NIOSH recommends that exposure to EGME and EGMEA in the workplace be limited to 0.1 parts per million (ppm) of air as a time weighted average for up to 10 hours/day in a 40 hour work week. NIOSH also recommended that exposure to EGEE and EGEEA be limited to the art engineering controls and work practices are to be used to bring about these reductions. EGME, EGEE, and their acetates are readily absorbed through the skin, thus making dermal contact unsafe.
NIOSH-Criteria-Document; Ethers; Glycols; Reproductive-system-disorders; Developmental-disorders; Embryotoxicity; Liver-damage; Skin-exposure; Skin-absorption; Testes; Kidney-damage; Nervous-system-disorders
109-86-4; 110-80-5; 110-49-6; 110-49-6
Numbered Publication; Criteria Document
NTIS Accession No.
DHHS (NIOSH) Publication No. 91-119
National Institute for Occupational Safety and Health
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division