Mutagenicity testing of selected industrial chemicals.
Ong-T; Taylor-G; Elliott-J; Golden-CA; Moon-RG
NIOSH 1980 May; :470-493
The mutagenic potentials of selected industrial chemicals and related compounds were evaluated. A total of 147 industrial chemicals and structurally related compounds were tested in the Ames/Salmonella assay using Salmonella-typhimurium strains (TA-98), (TA-100), (TA-1535), and (TA-1537) with or without metabolic activation by liver S9 mix from aroclor-1254 pretreated male Sprague- Dawley-rats. Five different concentrations of each chemical were used. The highest concentration was determined by the solubility and toxicity of the compound. A total of 120 compounds were not mutagenic, 23 were mutagenic to one or more of the strains, and four required metabolic activation. The authors conclude that a number of industrial chemicals have been found to be mutagenic in the Ames/Salmonella assay. These should be tested further in mammalian and submammalian systems.
Mutagenesis; In-vitro-studies; Microbial-test-systems; Organic-compounds; Platinum-compounds; Nitro-compounds; Halogenated-hydrocarbons; Bioassays
Kraybill-HF; Blackwood-IC; Freas-NB
Proceedings of the First NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, Rockville, Maryland, May 6-8, 1980