A review was presented which indicated that the studies on DNA adduct measurement have so far demonstrated that the techniques used have sufficient sensitivity for allowing their application to human samples. The advantages and disadvantages of each method was considered. The immunologic and post labeling methods were not able to provide absolute quantitation of adduct levels. The gas chromatography/mass spectrometry method was highly sensitive and specific, but its cost has precluded its use in large scale epidemiologic studies. While few samples have been analyzed by more than one method, those which have been have frequently presented conflicting results. This conflict was likely related to differences in specificity of the various assays used. Background levels of adducts were observed in most samples including those from unexposed referents. Large interindividual variations in adduct levels have also been observed in individuals with similar exposures. Presumably these differences result from differences in absorption metabolism and repair and demonstrate the advantage of biomonitoring, metabolism and repair over environmental monitoring.
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