Metabolic precursors of a known human carcinogen.
Moore-RM Jr.; Woolf-BS; Stein-HP; Thomas-AW; Finklea-JF
Science 1977 Jan; 195(4276):344
Recent studies have demonstrated that beta-naphthylamine (91598) (BNA) which is a known carcinogen is also a metabolite of N-phenyl- beta-naphthylamine (63020031) (PBNA) and also of 2-nitronaphthalene (581895) each of which was believed to be a relatively innocuous industrial compound. BNA was observed at a concentration level of 3 to 4 micrograms in urine samples from two volunteers injected with 50 milligrams of PBNA and from workers estimated to have inhaled 30 milligrams of PBNA. There were an estimated 15,000 workers with potential exposure to PBNA during its manufacture and use. NIOSH has recommended that more consideration be given to the assessment of metabolic pathways of chemical agents found in the workplace, that materials which can be metabolized by the human body to known carcinogens be handled in the same manner as carcinogens, that industrial hygiene practices be followed to minimize exposure to PBNA in the workplace, and that alternative chemicals to PBNA be fully evaluated.
NIOSH-Author; Rubber-manufacturing-industry; Metabolites; Metabolic-study; Synthetic-rubber-manufacturing; Amines; Occupational-exposure; Antioxidants; Humans; Naphthalenes
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