The clinical utility and reliability of asbestos bodies in bronchoalveolar fluid.
Schwartz-DA; Galvin-JR; Burmeister-LF; Merchant-RK; Dayton-CS; Merchant-JA; Hunninghake-GW
Am Rev Respir Dis 1991 Sep; 144(3)(Pt 1):684-688
The clinical relevance and reliability of bronchoalveolar lavage (BAL) as a measure of body burden of asbestos (1332214) in the lungs was investigated in occupationally exposed individuals. Seventy one subjects, all occupationally exposed to asbestos at high levels for 1 year and having a minimum of 20 years between first exposure and entry into the study, were tested through chest radiography, pulmonary function testing, high resolution chest computed tomography, BAL, and asbestos body analysis. The mean asbestos body count was 3.3 per milliliter BAL fluid. Of the subjects, 9.9% had no identified asbestos bodies in the 20 milliliter BAL samples. The concentration of BAL asbestos bodies was not significantly related to duration of exposure, time since first exposure, time since last exposure, occurrence of lung disease, or measures of either airflow, lung volumes, or gas exchange. The authors conclude that, compared to other reports in which asbestos bodies in BAL fluid represented valid measures of asbestos bodies in the lung parenchyma, these findings do not point to a significant relationship between the concentration of BAL asbestos bodies and measures of exposure or measures of asbestos induced lung disease.
NIOSH-Grant; Pulmonary-system-disorders; Clinical-techniques; Asbestos-fibers; Lung-burden; Asbestosis; Pulmonary-function-tests; Fibrous-bodies; Chest-X-rays; Occupational-exposure; Lung-disease; Humans
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
Pulmonary System Disorders
American Review of Respiratory Disease
University of Iowa, Iowa City, Iowa