Colchicine inhibits elevations in both alveolar-capillary membrane permeability and lavage surfactant after exposure of the rat to phosgene.
Ghio AJ; Hatch GE
Division of Allergy, Critical Care, and Respiratory Medicine, Duke University School of Medicine, Durham, North Carolina 1991 Jan; :1-28
Changes were measured in the permeability of the alveolar capillary membrane and lavage surfactant concentrations following phosgene (75445) exposure and the influence of colchicine on both. Male Sprague-Dawley-rats were treated with either colchicine at 1.0mg/kg or saline intraperitoneally 30 minutes prior to exposure to phosgene at 0.5 parts per million for 60 minutes and air. Lavage surfactant was quantified as the total phosphorus immediately and 1 day after exposure. The two sources of protein showed very different responses to phosgene. Permeability was elevated immediately but returned to normal values one day after inhalation. Values of total phospholipid in the lavage fluid showed no immediate differences between phosgene and air exposed rats. However, significant increases were observed 1 day after phosgene inhalation. Colchicine inhibited both the immediate rise in the permeability index and the elevation of total phospholipid 1 day after phosgene exposure.
NIOSH-Grant; Pulmonary-system-disorders; Alveolar-cells; Lung-irritants; Laboratory-animals; Respiratory-system-disorders; Pulmonary-function; Alveolar-cells; Toxic-gases
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Division of Allergy, Critical Care, and Respiratory Medicine, Duke University School of Medicine, Durham, North Carolina
University of Tenn Center Health Scien, Memphis, Tennessee