A procedure for the analysis of pentamidine isethionate in air.
Appl Occup Environ Hyg 1991 Nov; 6(11):920-921
Concerns regarding health care worker exposures to pentamidine (100334) prompted researchers at NIOSH to develop a sampling and analytical method for pentamidine in air. The method involves air sampling with a 37 millimeter polyvinyl-chloride membrane filter in an opaque cassette filter holder at 1 to 2 liters per minute, recovery of pentamidine-isothionate with 3 milliliter quantities of ethanol/water with 0.085% phosphoric-acid and 0.04% tetramethylammonium-chloride in an ultrasonic bath, and measurement by high performance liquid chromatography with fluorescence detection. The author notes that four studies are currently underway to evaluate health care workers' exposures to pentamidine using this procedure. These studies will evaluate exposure levels, assess control techniques, and evaluate health effects.
NIOSH-Author; Pharmaceuticals; Health-care-personnel; Air-quality-monitoring; Air-sampling-techniques; Air-quality-control; Sampling-equipment; Analytical-methods
Applied Occupational and Environmental Hygiene