NIOH and NIOSH basis for an occupational health standard. Acrylamide: a review of the literature.
Source
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 91-115, 1991 Jan; :1-43
Abstract
Information on acrylamide (79061) was reviewed as a basis for the development of an occupational health standard. Topics included: chemical properties, physical properties, production levels, uses, the potential for occupational exposure, occupational exposure limits, toxicology, methods for monitoring exposures, and adverse health effects from exposure. Acrylamide is a raw material used in the manufacture of polyacrylamides. It is an odorless, white, crystalline solid. The potential for occupational exposure to acrylamide exists in acrylamide manufacturing and processing, grouting operations, and research and analytical laboratories. The monomeric form has been found to be toxic, but tests have shown the polyacrylamide products to be generally nontoxic. Possible hazards include neurotoxicity, carcinogenicity, genotoxicity, and harmful effects to the reproductive system. Studies have confirmed that exposure to acrylamide can cause cancer and reproductive disorders in animals. However, epidemiological data are not available to confirm these findings in human workers.
Keywords
NIOSH-Author; Chromosome-disorders; Cytotoxic-effects; Reproductive-hazards; Laboratory-animals; Nervous-system-disorders; Neurotoxic-effects; Genotoxic-effects; Polymerization; Occupational-exposure
Document Type
Numbered Publication; Criteria Document
NTIS Accession No.
PB92-133222
Identifying No.
DHHS (NIOSH) Publication No. 91-115
Source Name
National Institute for Occupational Safety and Health
