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Current intelligence bulletin 55 - carcinogenicity of acetaldehyde and malonaldehyde, and mutagenicity of related low-molecular-weight aldehydes.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 91-112, (CIB 55), 1991 Sep; :1-50
A review of the data and a summary of findings regarding the potential carcinogenicity of acetaldehyde (75070) and malonaldehyde (542789) and the mutagenicity of related low molecular weight aldehydes were presented. Long term inhalation exposure of hamsters to acetaldehyde has produced laryngeal cancers and similar studies in rats have produced nasal cancers. Malonaldehyde produced adenomas and carcinomas of the thyroid gland and adenomas of the pancreatic islet cells during a long term gavage treatment of rats. Several assays have also shown that acetaldehyde and malonaldehyde have mutagenic properties. Adequate epidemiologic data were not available for workers exposed to acetaldehyde or malonaldehyde. Both chemicals meet the criteria of the OSHA to be considered potential carcinogens and NIOSH therefore recommends that worker exposures be reduced to the lowest feasible concentrations. The nine related aldehydes acrolein (107028), butryaldehyde (123728), crotonaldehyde (4170303), glutaraldehyde (111308), glyoxal (107222), paraformaldehyde (30525894), propionaldehyde (123386), propiolaldehyde (123386), and valeraldehyde (110623) are of concern because their chemical reactivities and mutagenic activities are similar to those of acetaldehyde and malonaldehyde and because they may be used as substitutes for formaldehyde.
NIOSH-Author; NIOSH-Current-Intelligence-Bulletin-No-55; Aldehydes; Mutagens; Laboratory-animals; Nasal-cancer; Gastrointestinal-system-disorders; Pancreatic-islets-neoplasms; Occupational-exposure
75-07-0; 542-78-9; 107-02-8; 123-72-8; 4170-30-3; 111-30-8; 107-22-2; 30525-89-4; 123-38-6; 123-38-6; 110-62-3
Numbered Publication; Current Intelligence Bulletin
NTIS Accession No.
DHHS (NIOSH) Publication No. 91-112; CIB 55
National Institute for Occupational Safety and Health
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division