Epidemiologic and toxicologic evidence of occupational cancer in metalworking and transportation equipment industries: Undercounting occupational disease.
Mirer-FE; Park-RM; Silverstein-MA
Ann NY Acad Sci 1989 Dec; 572:10-16
The principal focus of this report was a review of recent epidemiologic and toxicologic findings regarding occupational cancer in the metalworking and transportation equipment industries. Many workers have been exposed to chemicals in their industries at levels that are not thought to pose a carcinogenic risk, and yet the evidence presented in this reports suggested that the risk is real. Estimates of the fraction of cancer due to occupational exposures that depend on extrapolation of risk from the number of workers exposed to known single carcinogenic agents may understate the risk. According to the authors, mortality studies in industrial populations outside the chemical industry need to be expanded. Documentary evidence needed to determine quantitative exposure to chemicals in studied cohorts is not generally available. Laboratory toxicology should be driven by epidemiologic findings. Animal studies are lacking which indicate the effects of chronic exposure to basic materials in industry to which large numbers of workers are exposed. Worksite chemicals identified in this report which should be further studied include wood dust, solvents, foundry particulates, die release agents, coating, and cutting fluids.
NIOSH-Publication; Epidemiology; Carcinogenesis; Risk-factors; Carcinogens; Laboratory-animals; Risk-analysis; Metal-workers
Annals of the New York Academy of Sciences