Immune responsiveness in chlorine exposed rats.
Section of Allergy and Clinical Immunology, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 1991 May; :1-21
A mouse model was developed to test the hypothesis that acute exposure to high levels of chlorine (7782505) gas can increase sensitivity to inhaled antigen. This initial survey was designed to assess whether there was an increase in sensitivity to antigen and whether the effect was transient or of extended duration. BALB/c- mice were exposed to 200 or 150 parts per million (ppm) chlorine for 1 hour. The animals were then exposed to 1% aerosolized bovine serum albumin (BSA) immediately or 1, 3, 7, and 30 days after exposure. Exposures were for 30 minutes a day for 5 consecutive days. The findings indicated that in mice, acute exposure to 200ppm followed immediately by exposure to BSA resulted in increased levels of antigen specific immunoglobulin-G when compared to control values. Mice exposed acutely to lower levels of chlorine or to antigen at more distant time points following the irritant exposure did not demonstrate any increased antibody levels.
NIOSH-Grant; Pulmonary-system-disorders; Immune-reaction; Toxic-gases; Antibody-response; Laboratory-animals; Inhalation-studies; Toxic-effects
Medicine Tulane Medical Center 1700 Perdido Street New Orleans, LA 70112
Final Grant Report
NTIS Accession No.
Section of Allergy and Clinical Immunology, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana
Tulane University of Louisiana, New Orleans, Louisiana