Epithelial surface proteins: markers of cancer risk.
Merrill WW; Cullen MR; Carter D; Horwitz R; Matthay RA; Gee JB
Yale University School of Medicine, New Haven, Connecticut 1991 Feb; :-51
The relationship between proteins synthesized by airway mucosal cells and the presence of metaplasia detectable in biopsies of the bronchial mucosa was determined. Bronchoalveolar lavage and airway biopsies were performed on 50 subjects who had a history of occupational exposure to asbestos (1332214). All but eight of the subjects were current or former smokers. Metaplasia seen in mucosal biopsies and change in diffusion capacity for carbon-monoxide (CO) were used as surrogates for cancer risk and pulmonary fibrosis respectively. A third of the subjects showed keratinizing metaplasia, however, keratinizing metaplasia could not be related to levels of free secretory component or the keratins in lavage fluid. Cigarette smoking and the number of acute inflammatory cells were related to keratinizing metaplasia; nonsmokers had the lowest frequency of metaplasia, and current smokers had the highest frequency. When diffusion capacity was used as a surrogate for functional deterioration, acute inflammatory cells were statistically related to the rate of lung functional loss over time. Other occupational and demographic factors were not found to be significantly associated with metaplasia or functional deterioration.
NIOSH-Grant; Respiratory-system-disorders; Occupational-exposure; Asbestos-fibers; Asbestos-workers; Humans; Cigarette-smoking; Risk-analysis; Lung-function; Lung-cancer
Internal Medicine Yale University School of Med 109-Lci, P O Box 3333 New Haven, CT 06520
Final Grant Report
NTIS Accession No.
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders
Yale University School of Medicine, New Haven, Connecticut
Yale University, New Haven, Connecticut