Marked increase in the teratogenicity of the combined administration of the industrial solvent 2-methoxyethanol and radiofrequency radiation in rats.
Nelson-BK; Conover-DL; Brightwell-WS; Shaw-PB; Werren-D; Edwards-RM; Lary-JM
Teratology 1991 Jun; 43(6):621-634
The combined effects of exposure to radiofrequency (RF) radiation and 2-methoxyethanol (109864) (2ME) on developing rat fetuses was examined. CD-Sprague-Dawley-rats were exposed at 13 days gestation to RF radiation at a frequency of 10 megahertz, and their exposure to RF was adjusted to cause temperature elevations to 43.0, 42.5, 42.0 and 41.5 degrees-C. 2ME was administered at 250, 175, 150, and 125mg/kg by gastric lavage 5 minutes prior to RF exposure. Live fetuses were examined at 20 days of gestation for external malformations. Rats treated with 125mg/kg 2ME and RF to elevate rectal temperature to 42.0 degrees-C had decreased fetal weights and 76% of the fetuses from each of 18 litters were malformed. The malformations seen primarily involved the paws and tails. Fetal weights were reduced after exposure to RF or 2ME alone and 15 of 26 litters had fetuses with malformations after exposure to 2ME only, and 10 of 18 litters had malformed fetuses after RF exposure alone. No malformations were seen in rats sham treated for RF and chemical exposure. A significant synergistic effect between RF and 2ME exposure was verified statistically. The authors conclude that synergism between RF and 2ME administration results in increased fetal abnormalities.
NIOSH-Author; Laboratory-animals; Teratology; Radiation-effects; Electromagnetic-radiation; Embryopathology; Developmental-disorders; Organic-solvents; Nonionizing-radiation
B. K. Nelson, Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226