NIOSHTIC-2 Publications Search
Halogenated hydrocarbon toxicity in proximal tubules.
Hjelle JT; Miller MA
College of Medicine at Peoria, University of Illinois, Peoria, Illinois 1991 May; :1-11
A study was conducted to examine the validity of the isolated rabbit tubule model as a tool in the study of nephrotoxicants and to determine the validity of the rabbit tubule model as a predictor of nephrotoxicity in humans. Kidney proximal tubules were isolated from control and phenobarbital induced rabbits by nonenzymatic sieving techniques and then studied in-vitro. Proximal tubules obtained in bulk by nonenzymatic procedures were resistant to cell damage by levels of chloroform (67663) and carbon-tetrachloride (56235) likely to be encountered in the work place. Drug treatment of the rabbits followed by tubule isolation and exposure to these solvents in-vitro did not enhance cell damage. Tubule cells propagated in-vitro were more susceptible to cell damage caused by these organic solvents.
NIOSH-Grant; Grants-other; Laboratory-animals; Renal-toxicity; Chlorinated-hydrocarbons; Kidney-damage; In-vitro-studies
Basic Sciences University of Illinois One Illini Drive, Box 1659 Peoria, IL 61656
Final Grant Report
NTIS Accession No.
Other Occupational Concerns; Grants-other
College of Medicine at Peoria, University of Illinois, Peoria, Illinois
College of Medicine at Peoria, Peoria, Illinois
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division