Excess number of bladder cancers in workers exposed to ortho-toluidine and aniline.
Ward E; Carpenter A; Markowitz S; Roberts D; Halperin W
J Natl Cancer Inst 1991 Apr; 83(7):501-506
A retrospective cohort study of the incidence of bladder cancer among workers exposed to o-toluidine (95534) and aniline (62533) at a chemical facility in western New York State was conducted. The company was opened in 1946 for the production of polyvinyl-chloride. Production of an antioxidant for use in tire manufacturing started in 1957. A new rubber accelerator began production in 1970. The study population was divided into three groups: workers ever employed in the department where o-toluidine and aniline were used and therefore assumed to be definitely exposed; workers in maintenance, janitorial or yard work and shipping who were possibly exposed; and all other workers not likely to have been exposed. Among all 1749 workers at the site, 13 cases of bladder cancer were observed versus 3.61 expected. Among the 708 members of group-1, seven cases were observed versus 1.08 expected. Among the 288 members of group-2, four cases were observed versus 1.09 expected. Among the remaining 753 workers, two bladder cancers were noted versus 1.43 expected. Increased risk of bladder cancer was strongly associated with increased duration of employment in the department where o-toluidine and aniline were used.
NIOSH-Author; Rubber-manufacturing-industry; Cancer-rates; Risk-analysis; Risk-factors; Urogenital-system; Chemical-industry-workers; Chemical-manufacturing-industry; Epidemiology
Journal of the National Cancer Institute