Parental occupation and intracranial neoplasms of childhood: anecdotal evidence from a unique occupational cancer cluster.
Wilkins-JR III; McLaughlin-JA; Sinks-TH; Kosnik-EJ
Am J Ind Med 1991 May; 19(5):643-653
Towards the end of a data collection phase for a case/control interview study of childhood brain tumors and environmental factors, a case mother mentioned that each of three coworkers of her spouse was the parent of a child recently diagnosed with an intracranial neoplasms. Two additional children were then identified through these three. Each child had a parent employed at the same manufacturing facility. All six children were white; four were boys. The age at diagnosis ranged from 6 months to 14 years, 10 months. Two children had a diagnosis of astrocytoma, two a diagnosis of medulloblastoma, one a diagnosis of optic nerve glioma, and one a diagnosis of ependymoma. The observed/expected ratio was greater than 70. The six cases of childhood brain and central nervous system cancer were eight times more than would be expected among all persons under 20 years of age in the particular county. All case parents worked at the site at least 1 year prior to conception, during the index pregnancy, and for at least 6 months after birth. At this company more than 100 chemicals were used. According to the authors, it is unfortunate that the small number of case and the a-posteriori determinations of space/time boundaries limit the interpretations.
NIOSH-Author; Carcinogenesis; Neuropathology; Cancer-rates; Occupational-exposure; Electronics-industry; Brain-tumors; Humans; Reproductive-hazards
American Journal of Industrial Medicine