Acute ventilatory response to green coffee dust extract.
Zuskin-E; Kanceljak-B; Witek-TJ Jr.; Schachter-EN
Ann Allergy 1991 Mar; 66(3):219-224
The effect of green coffee extract was examined on the lung function of healthy subjects at rest and following mild exercise. The effect of pretreatment with disodium-cromoglycate (DSCG) on lung function changes following green coffee extract inhalation was also examined. Ten individuals were selected for their airway sensitivity to green coffee dust extract. There was a wide range of sensitivity to methacholine in this group. There was an overall statistically significant decrement in lung function over time on both test days following challenge with the green coffee extract. No statistically significant protective effect was noted after pretreatment with DSCG. Similar results were observed whether the subjects remained at rest or were involved in physical exercise. The authors conclude that extracts of green coffee dust cause bronchoconstriction in a significant proportion of healthy volunteers. The degree of bronchoconstriction by green coffee extract in naive healthy subjects is not enhanced by physical activity. The results suggest that coffee reactors exhibited mild hyperreactivity to methacholine. DSCG is not protective against the bronchoconstrictive effect of green coffee extract in this group.
NIOSH-Publication; NIOSH-Grant; Airway-resistance; Respiratory-system-disorders; Dust-exposure; Bronchial-asthma; Plant-dusts; Dust-inhalation; Food-processing-industry; Pulmonary-function-tests; Medical-treatment; Preventive-medicine
Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
Annals of Allergy
Mount Sinai School of Medicine, New York, New York