Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 91-103, 1991 Jan; :1-53
The propylene glycol ethers and their acetates were reviewed as background for discussion of occupational exposure limits. The most commonly used propylene glycols in industry were 1-methoxy-2- propanol (107982), 2-methoxy-1-propanol (1320678), 1-methoxy-2- propyl-acetate (108656), 2-methoxy-1-propyl-acetate (70657704) and dipropylene-glycol-monomethyl-ether (34590948). The report included information concerning ambient air levels at the workplace, analytical methods for air monitoring, toxicokinetics (uptake, probably routes of human exposure, distribution, biotransformation, elimination, and biological exposure indicators), general toxicology (toxic mechanisms and in-vitro studies, factors influencing toxicity, and general effects), organ effects (skin and mucous membranes, respiratory system, liver, kidneys, gastrointestinal tract, circulatory system, hematological system, central nervous system, and peripheral nervous system), immunotoxicity and allergy, mutagenicity, genotoxicity, carcinogenicity, reproductive toxicity, dose effect and dose response relationships (short term exposure, and long term exposure), and research needs.