Aluminum Inhalation Reduces Silicosis in a Sheep Model.
Begin-R; Dubois-F; Cantin-A; Masse-S; Dufresne-A; Perrault-G; Sebastien-P
NIOSH 1990 Nov:895-896
The efficacy of soluble aluminum-lactate (18917914) aerosol inhalation to alter the biological activity and disease process associated with silica (7631869) exposure was evaluated in the sheep tracheal lobe model. A flock of 40 sheep was divided into four groups of ten sheep. The first group was exposed to phosphate buffered saline (PBS) infusion in the tracheal lobe followed by monthly inhalation of PBS. The second group was exposed to PBS followed by monthly inhalation of aluminum-lactate. The third group was exposed to Minusil-5 followed by monthly inhalation of PBS. The fourth group was exposed to Minusil-5 followed by monthly inhalation of aluminum-lactate. Bronchoalveolar lavage was performed prior to exposures and at monthly intervals thereafter. Animals were sacrificed for histopathological examination at month 6. All silica exposed sheep demonstrated an increase in cellularity. Aluminum- lactate inhalation at monthly intervals significantly suppressed the alveolitis of silicosis, reduced the intensity and profusion of the disease process, and accelerated the clearance of quartz particles from the lung tissue. The authors conclude that soluble aluminum- lactate aerosol inhalation reduces silicosis in the sheep model without alteration of normal biological processes in the bronchoalveolar milieu or production of significant pathological lung damage.
Occupational-health; Occupational-exposure; Animal-studies; Silica-dusts; Occupational-diseases; Aluminum-compounds; Medical-treatment; Biological-effects; Lung-disease;
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference