New developments in asbestos-induced pleural disease.
Chest 1991 Jan; 99(1):191-198
Asbestos (1332214) induced pleural disease was reviewed and discussed. Topics included prevalence, pathogenesis, roentgenographic changes, pulmonary function, and determinants of restrictive lung function in pleural fibrosis. Studies have indicated that pleural fibrosis is the most common of the asbestos induced abnormalities. It has been underdiagnosed and has been associated with restrictive lung function which appeared to be independent of its association with parenchymal fibrosis. Little work has been done to investigate the accuracy of the current criteria for pleural fibrosis established by the ILO, the anatomic and functional validity of these criteria, and the determinants of restrictive lung function in persons with asbestos induced pleural fibrosis. Results from these studies will have clear implications for clinical assessment and management of workers with asbestos induced pleural disease. Several pieces of evidence suggested that parenchymal inflammation and/or fibrosis are the principle determinants of restrictive lung function in persons with asbestos induced pleural fibrosis who have normal appearing parenchyma on the chest radiogram. Findings suggested that although parenchymal inflammation and fibrosis contribute to the loss of lung function in persons with asbestos induced pleural fibrosis, other mechanisms may contribute to the impaired lung function.
NIOSH-Grant; Mineral-dusts; Occupational-exposure; Asbestos-workers; Respiratory-system-disorders; Lung-irritants; Lung-function; Airway-obstruction
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
Pulmonary System Disorders
University of Iowa, Iowa City, Iowa