Health hazard evaluation report: HETA-89-116-2094, Westinghouse Electric Corporation, Bloomington, Indiana.
Sinks-T; Smith-AB; Rinsky-R; Watkins-K; Shults-R; Steele-G
NIOSH 1991 Jan; :1-28
NIOSH conducted a retrospective cohort study of workers manufacturing electrical capacitors with known exposure to polychlorinated biphenyls (1336363) (PCBs) in an effort to further evaluate the carcinogenicity of PCBs. The study cohort manufactured electric capacitors in the midwest United States beginning in 1957. PCBs were used as a dielectric fluid until late in 1977 when they were replaced with isopropyl-biphenyl (25640782). Aroclor-1242 (53469219) was used through 1970 and Aroclor-1016 (12674112) was used afterwards. Included in the analysis were 3588 men and women employed for at least one day between January 1, 1957 and March 31, 1977. The results provided some evidence for an association between PCB exposure in an occupational environment and mortality from malignant melanoma. There was an increased incidence of brain cancer among workers who had more than twice the estimated cumulative PCB dose than the comparison group. The authors conclude that this brain cancer observation suggests that this outcome be carefully observed in further followup of this cohort.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; HETA-89-116-2094; Hazard-Confirmed; Region-5; Polychlorinated-biphenyls; Brain-damage; Central-nervous-system; Mortality-data; Occupational-exposure; Epidemiology; Chlorinated-hydrocarbons;
Author Keywords: Electrical industrial apparatus; polychlorinated biphenyl; PCB; Aroclor; malignant melanoma; brain cancer; mortality
1336-36-3; 25640-78-2; 53469-21-9; 12674-11-2
Hazard Evaluation and Technical Assistance; Field Studies
NTIS Accession No.
Hazard Evaluations and Technical Assistance Branch, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, Report No. HETA-89-116-2094, 28 pages, 37 references