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Chloracne associated with employment in the production of pentachlorophenol.

O'Malley-MA; Carpenter-AV; Sweeney-MH; Fingerhut-MA; Marlow-DA; Halperin-WE; Mathias-CG
Am J Ind Med 1990 Apr; 17(4):411-421
The occurrence of chloracne among pentachlorophenol (87865) (PCP) workers was evaluated, and the risk of chloracne among workers who had records of direct skin contact with PCP was assessed. The workers had been employed at a facility which had produced PCP from 1938 through 1978. Of the 926 hourly workers in the study cohort, 666 had medical records available and were employed in 1953 or later; 65 had a diagnosis of chloracne, of which 47 were thought to be associated with PCP. The increase in duration of exposure did not appear to be related to the increased risk of chloracne. Episodes of direct skin contact with PCP were reported throughout the history of the facility. The workers with independent records of direct skin exposure had overall a four fold increase in the risk of developing chloracne compared with workers who did not have records of direct skin contact. Eight of the 13 cases had only one episode of direct skin contact with PCP prior to the diagnosis of chloracne, three cases had two episodes, and two cases had three episodes. The interval between the latest episode of direct skin contact and the diagnosis of chloracne for these 13 cases ranged from about 7 weeks to about 14 years. Four of the 13 cases occurred within 6 months of contact, four occurred between 1 and 2 years after the skin contact. Two occurred between 2 and 3 years after contact and three occurred more than 10 years after exposure. The authors conclude that exposure to PCP contaminated with hexachlorinated, heptachlorinated, and octachlorinated dibenzo-p- dioxins and dibenzofurans was associated with the occurrence of chloracne.
NIOSH-Author; Preservatives; Chlorinated-hydrocarbons; Phenols; Epidemiology; Dioxins; Occupational-exposure; Chemical-factory-workers; Skin-exposure; Author Keywords: dioxin; occupational exposure; wood preservatives; epidemiology; hexachlorodibenzo-p-dioxin
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American Journal of Industrial Medicine