Mortality and cancer incidence among Swedish ceramic workers with silicosis.
Tornling-G; Hogstedt-C; Gustavsson-A; Westerholm-P
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Sep; (Part I):709-710
A study was made of mortality and cancer incidence in 314 male ceramic workers with silicosis, to assess the risk for lung cancer with exposure to quartz (14808607) not confounded by exposures to known lung carcinogens. Mortality was studied for the years 1951 to 1985, with total accumulated person years equal to 5695. Cancer incidence was studied for the years 1958 to 1983, with accumulated person years equal to 4247. Five year age categories were used for calculation of standardized mortality/morbidity rates (SMR). Excess mortality from respiratory tuberculosis (SMR 1932) and other nonmalignant respiratory diseases (SMR 746) contributed to increased overall mortality (SMR 138). Overall incidence of malignancies was not increased (SMR 94), but the SMR for lung cancer incidence was 188 (nine cases observed versus 4.8 expected). The lung cancer SMR was 236 using a latency time of 10 years from discovery of silicosis; this increased to 267 using a latency time of 20 years. Lung cancer diagnosis occurred 11 to 32 years after discovery of silicosis and 36 to 72 years after first exposure to quartz. The authors conclude that these results indicate an increased mortality from nonmalignant respiratory diseases and an increased incidence of lung cancer in ceramic workers with silicosis.
Ceramics-industry; Mortality-rates; Quartz-dust; Respiratory-system-disorders; Occupational-exposure; Cancer-rates; Lung-cancer; Respiratory-neoplasms; Morbidity-rates; Silica-dusts
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA