Study on Suppression of Soluble Aluminum Aerosols on Quartz-Induced Cytotoxicity - Combined Effects of Both Aerosols in an Artificial Dust Atmosphere.
NIOSH 1990 Nov:1299-1303
The cytotoxicity of aluminum (7429905) coated crystalline silica (14808607) (quartz) aerosols was evaluated in-vitro. Aerosols of soluble aluminum compounds (AlAs) and quartz were generated by an ultrasonic nebulizer. The amounts of aluminum adsorbed on the quartz particles and the particle size distributions of the aerosols were determined. Quartz aerosols containing 0 to 1.0 milligram per milliliter aluminum were generated and incubated with guinea-pig alveolar macrophages and rat erythrocytes. Cytotoxicity was assessed by measuring the extent of erythrocyte hemolysis and macrophage viability. The amounts of aluminum adsorbed on the quartz particles ranged from 0.09 to 0.15 micrograms per square centimeter. Coverage of the quartz surface by aluminum increased with decreasing particle size. The amount of aluminum adsorbed on a quartz particle with diameter 2.54 microns (micron) was nine times that of a particle having diameter 1.97micron. The aluminum coated particles were significantly less cytotoxic than the uncoated particles. The decrease in cytotoxicity generally increased with increasing concentration of adsorbed aluminum. The authors conclude that AlAs can combine with quartz particles to form stable dusts of aluminum coated particles. The aluminum coated particles are significantly less cytotoxic to macrophages and erythrocytes than uncoated particles.
Silica-dusts; In-vitro-studies; Cytotoxic-effects; Alveolar-cells; Red-blood-cells; Dust-exposure; Surface-properties;
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference