Studies on Preventive Effect of Aluminum Citrate on Silicosis.
Zou-S; Lui-H; Zhou-Y; Shu-K; Liu-S
NIOSH 1990 Nov:1237-1241
A study of the ability of aluminum-citrate (31142560) (Al-cit) to protect against silicosis was conducted. The cohort consisted of 519 Chinese coal miners and railway workers who were injected intramuscularly with 180 milligrams aluminum (7429905) as Al-cit annually for 5 years. The comparisons consisted of 398 coal miners and railways who received a placebo over the 5 year period. The subjects had radiographic opacities classified as 0 or 0(+) according to Chinese roentgenodiagnostic criteria. Chest X-rays were obtained every other year and read for silicosis. A total of 262 subjects and 180 comparisons were interviewed periodically throughout the period to obtain information about their symptoms. Blood and urine samples were collected and analyzed for lysozyme, calcium, serum-glutamic-pyruvic-transaminase, albumin-A, and gamma- globulin. Subjects receiving Al-cit treatment classified as 0 or at the end of the 5 year period. The corresponding prevalence rates of the comparisons were 12 and 26.0%, respectively. This indicated that Al-cit reduced the progression to silicosis of workers with 0 and 0(+) radiographic opacities by 86.6 and 60.4%, respectively. Subjects receiving Al-cit revealed a significantly decreased incidence of symptoms such as cough, thoradynia, and sputum production. Increased urinary excretion of albumin-A and decreases in serum gamma-globulin concentration were the only significant biochemical changes induced by Al-cit. The authors conclude that prophylactic therapy with Al-cit significantly retards development of silicosis.
Epidemiology; Respiratory-system-disorders; Aluminum-compounds; Prophylaxis; Coal-miners; Clinical-symptoms; Chest-X-rays; Physiological-chemistry;
DHHS (NIOSH) Publication No. 90-108
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference