Relationship between serum lipid peroxides and some immunological parameters in silicosis.
Authors
Tufanoiu E; Gabor S; Bochisiu L
Source
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1178-1180
The relationship between lipid peroxidation and humoral immune responses in silicotics was examined. The cohort consisted of 40 Romanian miners being treated for silicosis. The comparisons consisted of 40 age matched healthy individuals. Blood samples were collected and assayed for lipid peroxidation, immunoglobulin-A (IgA), immunoglobulin-G (IgG), and immunoglobulin-M (IgM). The extent of lipid peroxidation was determined by measuring the formation of thiobarbituric-acid reactive substances by means of the malondialdehyde technique. The concentrations of IgA, IgG, and IgM were determined by a radial immunodiffusion technique. The extent of lipid peroxidation was significantly elevated in the silicotic subjects relative to the comparisons, 5.8 nanomoles malondialdehyde per 0.5 milliliter (nmol/ml) versus 3.02nmol/ml. The silicosis patients had a significantly higher concentration of serum IgG relative to the comparisons, 270 International Units per ml (IU/ml) versus 150IU/ml. The concentrations of serum IgA and IgM in the silicotics did not differ significantly from those of the comparisons. The concentration of serum lipid peroxides in the silicotics was significantly correlated with the IgG concentrations. The authors conclude that free radical induced lipid peroxidation may play a significant role in the development of silicosis.
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.