Relationship between Serum Lipid Peroxides and Some Immunological Parameters in Silicosis.
Tufanoiu-E; Gabor-S; Bochisiu-L
NIOSH 1990 Nov:1178-1180
The relationship between lipid peroxidation and humoral immune responses in silicotics was examined. The cohort consisted of 40 Romanian miners being treated for silicosis. The comparisons consisted of 40 age matched healthy individuals. Blood samples were collected and assayed for lipid peroxidation, immunoglobulin-A (IgA), immunoglobulin-G (IgG), and immunoglobulin-M (IgM). The extent of lipid peroxidation was determined by measuring the formation of thiobarbituric-acid reactive substances by means of the malondialdehyde technique. The concentrations of IgA, IgG, and IgM were determined by a radial immunodiffusion technique. The extent of lipid peroxidation was significantly elevated in the silicotic subjects relative to the comparisons, 5.8 nanomoles malondialdehyde per 0.5 milliliter (nmol/ml) versus 3.02nmol/ml. The silicosis patients had a significantly higher concentration of serum IgG relative to the comparisons, 270 International Units per ml (IU/ml) versus 150IU/ml. The concentrations of serum IgA and IgM in the silicotics did not differ significantly from those of the comparisons. The concentration of serum lipid peroxides in the silicotics was significantly correlated with the IgG concentrations. The authors conclude that free radical induced lipid peroxidation may play a significant role in the development of silicosis.
Lipid-peroxidation; Blood-serum; Immunoglobulins; Dust-exposure; Respiratory-system-disorders; Immune-reaction; Underground-miners; Statistical-analysis;
DHHS (NIOSH) Publication No. 90-108
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference