Influence of Chemical/Thermal Pretreatment on the Cytotoxicity of Coalmine Dusts.
NIOSH 1990 Nov:1538-1541
An attempt was made to try to characterize the cytotoxicity of high rank and low rank mine dusts from the Saar and Ruhr coal fields more accurately via their dose dependence and the effect of chemical and thermal pretreatment. Two groups of dusts were selected for the chemical and thermal treatment. Group-A dusts caused higher reactions for one parameter in the animal experiments than for two parameters in the in-vitro test. Group-B dusts caused a lesser reaction for the one parameter in the animal experiment than in the corresponding two parameters of the in-vitro test. The chemical and thermal treatments resulted in a change in the toxicity of a number of the mine dusts, and generally towards an increase in toxicity. In view of the altered dust surfaces, these changes did not permit a direct assessment of the membrane toxicity. The treatment resulted in the removal of impurities from the dust surface. With quartz (14808607) the treatment also resulted in a change in the basic crystal structure and therefore in the electron structure. The mine dusts from Group-A differed more widely than those of Group-B with regard to their quartz typical deposition areas in the lymph node test than the quartz contents of the dusts.
Cytotoxic-effects; Coal-dust; Dust-inhalation; Dust-exposure; Airborne-dusts; Mining-industry; Silica-dusts;
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference