Muscularization of Pulmonary Arteries in Coal Workers Pneumoconiosis.
Hu-N; Vallyathan-V; Green-FH; Weber-KC
NIOSH 1990 Nov:1526-1534
An investigation was conducted to examine the differences between the etiology and pathophysiology of two types of muscular hypertrophy in the terminal pulmonary arterial trees in coal worker's pneumoconiosis (CWP), namely longitudinally oriented and circularly oriented smooth muscle hypertrophy. For this investigation 72 autopsies without heart valvular or severe coronary lesions and without hypertensive left ventricular hypertrophy were drawn from a series of 120 unselected consecutive autopsies. The results indicated that circular smooth muscle hypertrophy in the medial wall of pulmonary arterioles demonstrated a high correlation with the incidence of right ventricular hypertrophy (RVH) in 57 CWP cases and 15 referent cases from the Appalachian region. Intimal longitudinal muscle hypertrophy, or medical circular muscle hypertrophy in small pulmonary arteries did not reveal such correlation with RVH.
Respiratory-system-disorders; Lung-disease; Cardiovascular-system-disorders; Coal-workers-pneumoconiosis; Coal-dust; Dust-exposure; Postmortem-examination;
DHHS (NIOSH) Publication No. 90-108
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference