Alveolitis in occupational lung disease (OLD).
Teles de Araujo-A; Mendes-AC; Monteiro-JT; Costa-MF
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1514-1518
An investigation was conducted to evaluate the existence and type of alveolitis among a group of 48 patients with occupational lung disease confirmed by the usual criteria. A comparison was also made of the patients with occupational history of exposure to organic dust (Group-I) with patients exposed in work environment to mineral dust (Group-II). The cellular analysis of bronchoalveolar lavage (BAL) fluid noted an increased number of cells, with a significant difference in Group-I as compared to referents. The alveolitis in both groups was mainly due to a significant increase in lymphocytes. A slight but not significant increase in the polymorphonuclear cells was also noted. Among the 14 patients in which lung biopsy was performed, alveolitis was noted in the BAL of nine. From these nine, eight demonstrated granulomas or lymphoplasmocytary infiltration of the alveolar septa. From the five patients without alveolitis in BAL only one presented granulomas in the lung biopsy. A marked increase was noted in the T-suppressor cells. The authors conclude that BAL is a good method to investigate occupational lung diseases as it contributes to the staging and understanding of the pathogenic mechanisms.
Diagnostic-techniques; Respiratory-system-disorders; Lung-disease; Dust-exposure; Dust-inhalation; Mineral-dusts; Silica-dusts; Occupational-diseases
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA