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The Single Breath Diffusing Capacity Measurement as a Predictor of Exercise Induced Oxygen Desaturation in Patients with Silicosis.

Ratkalkar-K; Rambaran-N; Mezic-E; Nicewicz-JT; Murphy-DM
NIOSH 1990 Nov:1481-1484
An investigation was conducted to determine the capacity of the single breath diffusing capacity measurement to predict exercise induced hypoxemia in patients with both simple and conglomerate silicosis. Of the nine subjects examined, 44 to 72 years of age, four had simple silicosis and five had conglomerate silicosis. Two had a normal resting single breath diffusing capacity. One of these two had a decrement in arterial oxygen tension of 11 torr on exercise. Seven of the nine with resting single breath diffusing capacity of less than 80% of predicted had decrements in arterial oxygen tension ranging from 5 to 20 torr on exercise. Three of those with conglomerate silicosis had decrements in oxygen saturation of more than 5% on exercise. The results indicated that the single breath diffusing capacity measurement at rest appeared to predict exercise induced decrements in arterial oxygen tension and/or oxygen saturation. Abnormalities in gas exchange as demonstrated by increased alveolar atrial oxygen difference and dead space/tidal volume ratios were observed in all subjects during exercise.
Respiratory-system-disorders; Lung-function; Physical-exercise; Lung-disease; Silica-dusts; Dust-inhalation; Lung-irritants; Pulmonary-function-tests;
Publication Date
Document Type
Conference/Symposia Proceedings;
Fiscal Year
NTIS Accession No.
NTIS Price
Identifying No.
DHHS (NIOSH) Publication No. 90-108
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Source Name
Proceedings of the VIIth International Pneumoconioses Conference