Cytotoxicity and Spectroscopic Investigations of Organic Free Radicals in Fresh and Stale Coal Dust.
Dalal-NS; Jafari-B; Vallyathan-V; Green-FY
NIOSH 1990 Nov:1470-1477
An investigation was conducted using cytotoxicity and spectroscopic analyses to examine organic free radicals in fresh and stale coal dust. A description was provided of the time dependence of the decrease in the free radical content of a freshly made anthracite dust and of the dust's cytotoxicity potential as measured by the extent of hemolysis of sheep erythrocytes. The effects of free radical scavengers on the cytotoxicity potential of the dust were investigated. The freshly made anthracite coal dust was more cytotoxic than the stale dusts from the same stock. Surface oxidation reactions involving free radical sites on the coal particles were important in the dusts cytotoxicity. The authors conclude that indeed the free radicals could play a significant role in the initial events in the mechanism of the cytotoxic effects due to the inhalation of coal dust.
Cytotoxic-effects; Coal-dust; Dust-inhalation; In-vitro-study; Airborne-dusts; Cell-damage; Lung-cells; Analytical-chemistry; Respiratory-system-disorders;
DHHS (NIOSH) Publication No. 90-108
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference