Hyaline pleural plaques and asbestos exposure.
Bianchi C; Brollo A; Ramani L
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):919-923
The relationship between hyaline pleural plaque formation and asbestos (1332214) exposure was examined. Lung tissue specimens from 1620 residents (1040 males) of the Monfalcone Territory, Italy were obtained at autopsy. A large number of the subjects had been employed at Monfalcone shipyard, the major employer in the region. The tissue specimens were examined for hyaline pleural plaques and asbestos bodies. The relatives of 745 subjects were interviewed to obtain information on occupational history. The largest number of plaques occurred in males who died between the ages of 35 and 84 years and in females who died between the ages of 55 and 84 years. The overall prevalence of plaques in the male subjects was significantly larger than in the females. The prevalence of all pleural plaques and large pleural plaques in the males was significantly higher than in the general population. The prevalence of all plaques and small plaques in female subjects was significantly larger than in the general population. The prevalence of asbestos bodies in male subjects was significantly higher than in the females. The number of asbestos bodies was significantly correlated with the extent of pleural plaque formation. Males who had been employed at a shipyard or in the chemical and construction industry had a significantly higher prevalence of pleural plaques than those who had been employed in agriculture. Female subjects who had a history of domestic asbestos exposure, such as from cleaning work clothing of family members employed at the shipyard or in the chemical industry, had a significantly higher prevalence of pleural plaques than those without such exposure. The authors conclude that the high prevalence of pleural plaques among Monfalcone males represents occupational exposures in shipbuilding or chemical production. The high prevalence of plaques in the females can be attributed to domestic asbestos exposure.
Epidemiology; Lung tissue; Asbestos dust; Occupational exposure; Environmental exposure; Lung lesions; Sex factors; Postmortem examination; Shipyard workers
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA