Asbestos related diffuse pleural fibrosis.
Gibbs-AR; Griffiths-DM; Stephens-M; Pooley-FD
NIOSH 1990 Nov; :915-918
Mineral fiber concentrations in lung tissue from persons with diffuse pleural fibrosis (DPF) attributed to asbestos (1332214) exposure were determined. Tissue specimens from the pleural, subpleural, and central areas of lungs were obtained at autopsy from 13 males who had bilateral DPF. The degree of parenchymal fibrosis was determined using a 4 point scale. The clinical and occupational histories of the subjects were reviewed. The samples were analyzed for chrysotile (12001295), crocidolite (12001284), and amosite (12172735) by scanning and transmission electron microscopy. The ages at death of the subjects ranged from 47 to 80 years. The years of potential exposure to asbestos ranged from 1 to 35 years. The degree of parenchymal fibrosis in 12 subjects ranged from 0/1 to 2/3. Parietal pleural plaques were seen in some subjects. One subject had severe diffuse pericardial fibrosis. Total asbestos fiber counts were significantly elevated in tissue samples from 11 subjects. Total asbestos fiber counts were significantly higher in the central and subpleural regions than in the pleural regions. Chrysotile fibers were generally equally distributed throughout all lung regions. Amosite and crocidolite concentrations in the pleural region were significantly lower than in the central or subpleural region. The authors conclude that the DPF in 11 subjects was probably caused by occupational exposure to asbestos. In DPF cases chrysotile is the predominant fiber found in the pleura, but small amounts of amphibole fibers are also present.
Lung-tissue; Postmortem-examination; Asbestos-fibers; Lung-fibrosis; Occupational-exposure; Asbestos-workers; Mineral-dusts;
1332-21-4; 12001-29-5; 12001-28-4; 12172-73-5;
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference