Behavioral toxicity in silicotic patients (pilot study).
Song F; Zhang J; Yuan G; Wu S; Chen F
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1573-1575
In order to explore the neuropsychological impairment in silica dust exposed workers, the Wechsler Adult Intelligence Scale Revised in China (WIAS-RC) was used along with some of the tests on the Wechsler Memory Scale Revised in China (WMS-RC) to examine eight men and one woman exposed to silica (14808607) dust. All had been exposed for at least 4 years and had been diagnosed as silicotic. Almost all of the subjects received full scores on experience and orientation subtests of WAIS-RC. Seven of nine cases got only a zero scaled score on the test of counting from 1 to 100. No one could completely recall a short story and no one could get more than a scaled score of seven on counting backward from 100. More than half failed to perform some subtests on WAIS-RC. The findings suggest that patients with silicosis suffered from some impairment of short term memory, but remote memory was spared. The poor performance on subtests of reversed counting and digits backward indicate that the mental tracking ability was markedly impaired. The patients did serial counting from 7 to 100 very slowly and most got only zero scaled score. The authors conclude that silica dust exposure caused chronic toxic effects on human behavior similar to those arising from organic solvent exposures.
Psychological effects; Nervous system disorders; Silica dusts; Dust exposure; Occupational exposure; Humans; Pneumoconiosis
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA