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Silica - is it a carcinogen in the respiratory tract?

Authors
Craighead-JE
Source
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1162-1164
NIOSHTIC No.
00198592
Abstract
Results were presented of an evaluation of current epidemiological and medical information in an attempt to determine whether silica (7631869) acts as a carcinogen in the respiratory tract. The experimental evidence obtained from animal studies has suggested a possible role of silica in the pathogenesis of bronchogenic carcinomas, however these studies were noted incomplete. The epidemiological studies in humans were also reviewed and the author concludes that they provide insufficient evidence to permit one to conclude that man is at increased risk of developing carcinoma of the lung as a result of silica dust exposure. These results in no way should exclude silica from consideration as a cause of bronchogenic carcinoma, but they do point out the inadequacies of the contemporary scientific information and emphasize the need for additional, carefully designed systemic studies.
Keywords
Air-quality-monitoring; Airborne-dusts; Silica-dusts; Tissue-distribution; Lung-burden; Respiratory-system-disorders; Lung-cancer; Risk-factors; Epidemiology
CAS No.
7631-86-9
Publication Date
19901101
Document Type
Conference/Symposia Proceedings
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Identifying No.
DHHS (NIOSH) Publication No. 90-108
Source Name
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
State
PA
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