Silica - is it a carcinogen in the respiratory tract?
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1162-1164
Results were presented of an evaluation of current epidemiological and medical information in an attempt to determine whether silica (7631869) acts as a carcinogen in the respiratory tract. The experimental evidence obtained from animal studies has suggested a possible role of silica in the pathogenesis of bronchogenic carcinomas, however these studies were noted incomplete. The epidemiological studies in humans were also reviewed and the author concludes that they provide insufficient evidence to permit one to conclude that man is at increased risk of developing carcinoma of the lung as a result of silica dust exposure. These results in no way should exclude silica from consideration as a cause of bronchogenic carcinoma, but they do point out the inadequacies of the contemporary scientific information and emphasize the need for additional, carefully designed systemic studies.
Air quality monitoring; Airborne dusts; Silica dusts; Tissue distribution; Lung burden; Respiratory system disorders; Lung cancer; Risk factors; Epidemiology
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA