Silica - is it a carcinogen in the respiratory tract?
NIOSH 1990 Nov; :1162-1164
Results were presented of an evaluation of current epidemiological and medical information in an attempt to determine whether silica (7631869) acts as a carcinogen in the respiratory tract. The experimental evidence obtained from animal studies has suggested a possible role of silica in the pathogenesis of bronchogenic carcinomas, however these studies were noted incomplete. The epidemiological studies in humans were also reviewed and the author concludes that they provide insufficient evidence to permit one to conclude that man is at increased risk of developing carcinoma of the lung as a result of silica dust exposure. These results in no way should exclude silica from consideration as a cause of bronchogenic carcinoma, but they do point out the inadequacies of the contemporary scientific information and emphasize the need for additional, carefully designed systemic studies.
Air-quality-monitoring; Airborne-dusts; Silica-dusts; Tissue-distribution; Lung-burden; Respiratory-system-disorders; Lung-cancer; Risk-factors; Epidemiology
DHHS (NIOSH) Publication No. 90-108
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders
Proceedings of the VIIth International Pneumoconioses Conference